Miguel Pappolla, M.D.

Miguel Pappolla, MD

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Dr. Pappolla’s training includes medical residencies and fellowships training in Neurology and Pain Medicine (Anesthesia based) and also in Clinical Pathology, Anatomic Pathology, and Neuropathology. This training required 10 additional years of formal medical education (following graduation from Medical School) all pursued in programs accredited by the American Board of Medical Specialties, considered the “gold standard” in physician education in the United States. Dr. Pappolla holds active board certifications in 5 disciplines of Medicine (Pain Management, Neurology, Anatomic Pathology, Clinical Pathology and Neuropathology). He has also been serving the public at large for over 20 years as a consultant for the NIH (National Institutes of Health) and a full Professor or Faculty at several of the most prestigious medical schools in the USA (LSU New Orleans, Mount Sinai Medical School in New York City, University of Texas at Houston) where he taught Neurosciences to medical students and medical residents for over 20 years. Dr. Pappolla has also served as Chairman of Neurology and Director of Neurosciences in one of the largest tertiary care centers in Mississippi, till about the time when his practice was disrupted by hurricane Katrina. His scientific work includes more than 100 publications and book chapters in neuroscience. Dr. Pappolla’s research is cited in thousands of textbooks worldwide (for independent analysis, please view some of the research cited by clicking here). Also, please click here “Pappolla CV” for more detailed information on his credentials.

Dr. Pappolla has been among the very first investigators to identify evidence of oxidative stress in Alzheimer’s disease brain. This has led to neuroprotective strategies worldwide currently under development. Along with Dr. Larry Refolo, Dr. Suzana Petanceska at the National Institutes of Health (NIH) and others, he conducted groundbreaking research on cholesterolemia as an early risk factor for Alzheimer’s disease. As a neuropathologist, he described several unique neuropathologic lesions including the colloid body of Parkinson’s disease (later renamed “pale body”) and the ubiquitinylated “dot-like inclusions” in the aged brain. One other area of research is the development of neuroprotective drugs. He produced several patents; one of these drugs is currently on phase 2 clinical trial for Friedriech’s ataxia (OX1, a melatonin analog) and melatonin-related analogs for Alzheimers disease. 

Dr. Pappolla’s goal and that of all the staff at St. Michael’s is to place our experience and dedication at the service of patients in our communities in Texas. The St. Michael’s Pain and Spine Clinics provide care for back pain, neck pain, spine disorders, headache and other chronic pain disorders in Houston, Pasadena, NASA, Clear Lake and surrounding communities. We pride ourselves in having a professional, experienced team of health care specialists who attend to patients in a compassionate low-stress environment. For patients with chronic pain, the St. Michael’s approach is multidisciplinary. We work closely with many other specialists including neurologists, psychologists, orthopedic and spine surgeons, physiatrists, oncologists, and psychiatrists to optimally coordinate the care of our patients.

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